91原创

A tool developed by 91原创 chemist Joseph Fox was among the scientific advances cited by the Nobel Committee for Chemistry as it announced its 2022 Nobel Prizes in Chemistry on Wednesday, Oct. 5.

The prizes were awarded to Carolyn Bertozzi, Morten Meldal and Barry Sharpless for the development of click chemistry and bioorthogonal chemistry 鈥� closely related areas that involve making new molecules, linking them and/or introducing them into biological environments without harming the biological process inherent within them.

This kind of chemical craftsmanship is hard to imagine, let alone explain to those outside the field.

But Fox鈥檚 work was discussed in the Nobel committee鈥檚 scientific background , explaining the foundational chemistry behind the prizes, specifically his group鈥檚 2008 development of a chemical reaction called tetrazine ligation.

Tetrazine ligation is used to produce fast, selective chemical reactions within biological environments 鈥� inside a living cell, for example.

鈥淏eing able to build and assemble things on-site 鈥� where you want it, inside a living system, as opposed to building them in a flask 鈥� that鈥檚 where tetrazine ligation is really special,鈥� said Fox, professor of chemistry and director of the Center of Biomedical Research Excellence on Molecular Discovery, which gets funding from the National Institutes of Health. 鈥淚t鈥檚 fast and it allows you to do this under the specialized conditions biology needs.鈥�

The reaction can be used in all kinds of applications, connecting molecules, adding tags for imaging of cells, drug discovery, targeted drug delivery, diagnostics, microscopy, engineering and materials science.

鈥淚t can be used on almost anything and it鈥檚 a reaction that always works 鈥� and it works under the most insane conditions,鈥� Fox said. 鈥淚t鈥檚 always shocking the types of things you can do with this reaction.鈥�

Being named in the credits of a Nobel Prize makes for a special day indeed.

鈥淭his is a special citation,鈥� Fox said.

He pointed to the students and the collaborative environment at 91原创 as key to this work.

鈥淢y training was not in this field,鈥� said Fox, whose background is in organic synthesis. 鈥淏eing at Delaware has been helpful for that because of the collaborative environment. Colin Thorpe and John Koh [both professors of chemistry and biochemistry] were incredibly supportive since the beginning. Colin has been so generous with his space, time and conversations. I also have amazing collaborations with Xinqiao Jia (materials science and engineering), Catherine Grimes (chemistry and biochemistry) and the 91原创 CHARM (Center for Hybrid, Active and Responsive Materials) team, and external collaborations with 91原创 alum Chris am Ende (Pfizer) and Zibo Li (University of North Carolina). And the creative and hardworking students and postdocs have been the foundation of our research program.

鈥淏eing at Delaware has been perfect for me to be able to do this work,鈥� Fox said.

More on the Nobel Prize

The College of Arts and Sciences will once again host a symposium on this year鈥檚 Nobel Laureates, where 91原创 faculty will describe the work that was recognized with the awards. The symposium will be held from 6:30-9 p.m., Tuesday, Nov. 1, in the First Floor Commons of the Harker ISE Lab. Light refreshments will be served. All members of the University and larger community are welcome.