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Education

• B.Sc.Ìý- The University of Pune, India, 1994
• M.Sc.Ìý- The University of Pune, India, 1996
• Ph.D.Ìý- The University of Iowa, Iowa City, 2003
• PostdocÌý- Harvard Medical School and Brigham and Women's Hospital, 2003-2010
• Instructor in MedicineÌý- Harvard Medical School, 2011

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Teaching

Salil Lachke teaches Molecular Biology of the Cell BISC401 (Honors), gives lectures in Biochemical Genetics BISC654 and serves as an instructor for undergraduate research taken for credit in BISC468. He a​lso serves as research advisor for undergraduate Senior Thesis, graduate Masters Thesis, and Doctoral Dissertation.​

Research Interests

The Lachke laboratory uses interdisciplinary approaches for the identification and functional elucidation of genes involved in organ development and disease. We have developed a bioinformatics approach termed "" (integrated Systems Tool for Eye gene discovery,Ìý) and have successfully used it to identify novel cataract genes and predict several other uncharacterized genes with function in lens development.Ìý Our goal is to characterize these genes using biochemical, molecular, cell biological, and omics-level approaches. ÌýAs an important step toward this goal, we have used iSyTE toÌýuncover the role of several new regulators, including CAPRIN2, CELF1, ELAVL1, RBM24, and TDRD7 (post-transcriptional regulatory RNA-binding proteins) and ELL2, MAFG and MAFK (transcription regulators) in lens development and cataractogenesis (,Ìý,Ìý,Ìý,Ìý,Ìý).Ìý Our long-term mission is to define the gene regulatory networks (GRNs) that underlie organogenesis, in order to devise new therapies.Ìý In addition to its clinical significance, we anticipate that insights gained from this research can unveil fundamental regulatory principles underlying cellular differentiation and organogenesis.